Selectins and their counter receptors: a bitter sweet attraction.
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Selectins and their counter receptors: a bitter sweet attraction.
Selectins are adhesion receptors expressed by leucocytes, platelets, and endothelial cells. They mediate the initial binding of leucocytes to vascular endothelium in the post-capillary venules. This is an essential first step in leucocyte migration into tissue. The selectin family of adhesion receptors consists of three C-type lectins (E, P, and L selectin). Their ligands (counter structures) a...
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Recent data have shown that a group of cell surface proteins, originally studied independently as lymphocyte homing receptors or as activation-induced surface proteins of platelets and/or endothelial cells (Stoolman, 1989) are structurally related. Each is an integral membrane protein with an N-terminal, C-type lectin domain followed by an EGF-like module, multiple copies of the consensus repea...
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ژورنال
عنوان ژورنال: Thorax
سال: 1996
ISSN: 0040-6376
DOI: 10.1136/thx.51.11.1155